A major contraindication to NSAID use includes which condition?

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Multiple Choice

A major contraindication to NSAID use includes which condition?

Explanation:
NSAIDs can reduce prostaglandin production, and prostaglandins help keep renal blood flow adequate. In significant kidney disease, the kidneys already struggle to maintain filtration, so blocking prostaglandins can sharply decrease renal perfusion and worsen kidney function or trigger acute kidney injury. That risk makes significant kidney disease a major contraindication to NSAID use. Adequate hydration, by supporting kidney perfusion, is not a contraindication. Having no medical history or engaging in regular exercise likewise does not by itself rule out NSAID use.

NSAIDs can reduce prostaglandin production, and prostaglandins help keep renal blood flow adequate. In significant kidney disease, the kidneys already struggle to maintain filtration, so blocking prostaglandins can sharply decrease renal perfusion and worsen kidney function or trigger acute kidney injury. That risk makes significant kidney disease a major contraindication to NSAID use.

Adequate hydration, by supporting kidney perfusion, is not a contraindication. Having no medical history or engaging in regular exercise likewise does not by itself rule out NSAID use.

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